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Stocks
Lantheus Holdings, Inc.
LNTH

LNTH Lantheus Holdings, Inc.

Lantheus Holdings, Inc. · NASDAQ
Market Closed
100.25
▼ ⁦-0.14%⁩ (-0.14)
Market Cap$6.5B
Beta-0.06
52w Low52w High
49.67111.86
Last Week
⁦-0.56%⁩
Last Month
⁦-0.72%⁩
Last 3 Months
⁦+0.96%⁩
Last Year
⁦+76.37%⁩
EL7 Factor Analysis
How we score this
Overall92
Excellent — top fifth of the marketHigh FlyerF 5/9SafeBetter than 92% of Market stocks, per EL7's model
FactorScoreDistributionValueAvgRank
▸
Valuation
43
24.0x▼17.8xAround median
▸
Growth
44
2.3%▼7.1%Around median
▸
Quality
89
11.5%▲4.5%Top tier
▸
Safety
85
0.1x▲2.6xTop tier
▸
Capital Return
45
—2.12%Around median
▸
Momentum
93
81.4%▲2.9%Top tier
▸
Sentiment
62
9▲3Around median
Fair Value
Current price$100
Analyst target · 4 analysts
$103
⁦+2%⁩
See it fairly priced
Range ⁦$94–$120⁩
vs
DCF (estimate)
$99
⁦-2%⁩
Sees it fairly priced
⁦7.9⁩% discount · ⁦0⁩% growth
Bottom lineThe two methods broadly agree — estimate range ⁦$99–$103⁩.

Estimates — analyst targets and a simplified DCF, not investment advice.

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Monthly plan
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Analyst Consensus

This section combines price targets, revision history, analyst coverage changes, and an AI summary of what changed on the Street.

Price Target· 4 analysts setting price target
$105.27
⁦+5.0%⁩
Current Price $100.25·Median $102.50
Low
$94.00
High
$120.00
Current price
$100.25
Average target
$105.27
Street summary

Negative shift in analyst outlook for Lantheus stock

Bearish tilt

Lantheus (LNTH) stock saw a notable decline in analyst confidence during August 2026, as the average price target fell by 6.22% to reach $105.27 compared to $112.25 in the previous month. This decline coincided with a wave of rating downgrades by four major financial institutions (B. Riley, TD Cowen, William Blair, and CJS Securities) that moved their ratings for the stock from "Buy" to "Neutral" and "Hold," reflecting increased caution regarding the stock's near-term prospects.

As of 2026-08-24
Revisions momentum · 30d
⁦+0.0%⁩
Average rating
★ 3.36
Hold
Analyst coverage
11
Buy conviction
27%
Rating activity · 30d
0↑ · 1↓
Target dispersion
26%
Analyst ratings over time11 analysts rating
1
2
8
Strong BuyBuyHoldSellStrong Sell
Rating trend — last 12 months4.00 → 3.36
Recent analyst moves
  • ⬇ Downgrade2026-08-17
    B. Riley
    BuyNeutral
  • ⬇ Downgrade2026-08-04
    CJS Securities
    Market Perform
  • ⬇ Downgrade2026-08-03
    TD Cowen
    BuyHold
Premium content
Key Financials

Ten ratios that matter, each compared against its sector median and average — so you can see whether a number is rich or cheap relative to peers in the same sector.

StockSector medianSector averagetypical sector range
MetricValuePosition within sectorVerdict
  • P/E (TTM)
    23.98x
    3.94x44.30x
    Near median
  • Forward P/E
    18.07x
    4.64x37.16x
    Cheap
  • EV / EBITDA
    18.01x
    3.77x30.13x
    Cheap
  • FCF Yield
    6.0%
    -138.2%7.8%
    Strong
  • Revenue Growth YoY
    2.3%
    -56.9%93.8%
    Near median
  • EPS Growth YoY
    11.2%
    -160.1%130.2%
    Above average
  • Gross Margin
    60.1%
    12.8%90.7%
    Above average
  • ROIC
    11.5%
    -155.3%16.0%
    Strong
  • Net Debt / EBITDA
    0.10x
    0.60x5.10x
    Low debt
  • Dividend Yield
    —
    —
  • Payout Ratio
    —
    —
  • Altman Z-Score
    5.47
    -38.7417.53
    Strong
Financial Analysis
|

Stock Analysis

AI-generated
Based on 2026-05-07 data

Company Overview

Lantheus Holdings operates in medical diagnostics based on radiopharmaceuticals and imaging enhancement agents. In Q1 FY2026, most revenue came from PYLARIFY, a PSMA PET imaging agent for prostate cancer, alongside NEURACEQ for imaging beta-amyloid associated with Alzheimer's disease and DEFINITY for ultrasound imaging enhancement, as well as its pharmaceutical solutions and strategic partnerships. The company relies on a network of radiopharmaceutical manufacturing sites and its relationships with nuclear medicine departments to expand the availability and geographic reach of these products.

In Q2 FY2026, Lantheus reported revenue of $388.2 million, gross profit of $241.9 million, net income of $75.0 million, and earnings per share of $1.11. These figures equate to a gross profit margin of approximately 62.3% and a net income margin of approximately 19.3%. Trailing twelve-month revenue was $1.6 billion, with gross profit of $936.0 million and net income of $275.3 million.

The latest available mix details, for Q1 FY2026, show that PYLARIFY generated $240.9 million, or approximately 63.8% of quarterly revenue of $377.3 million. NEURACEQ generated approximately $35.4 million, DEFINITY approximately $84.6 million, while revenue from strategic partnerships and other activities totaled $16.3 million. Adjusted gross profit margin was 67.0%, while adjusted operating income reached $129.1 million and adjusted net income reached $95.8 million.

What's Driving the Stock

  • PYLARIFY TRUVU received FDA approval on March 6, 2026, and Lantheus is targeting a site-by-site geographic conversion beginning in Q4 FY2026 after completing coding and coverage and ensuring claims systems are ready. Management explained that more than 70% of PYLARIFY doses are already produced at sites equipped with high-energy cyclotrons, which may enable larger batches and broader geographic reach, with a meaningful revenue contribution expected in FY2027.
Earnings callEDGAR filings30-day newsInsider activity

Automated analysis for informational purposes only — not investment advice.

  • NEURACEQ generated revenue of $35.4 million in Q1 FY2026, up 14.3% compared with Q4 FY2025. The number of manufacturing sites in its network increased to 22, and management links its growth to increased use within existing accounts, the adoption of disease-modifying Alzheimer's treatments, and guidelines supporting early diagnosis.
  • DEFINITY remained a stable source of growth, with revenue reaching $84.6 million in Q1 FY2026, up 6.8% year over year, driven primarily by higher demand volume. The company says its market share exceeds 80%, with the product firmly embedded in clinical workflows after 25 years of use.
  • On the May 7, 2026 call, management maintained FY2026 guidance for revenue of $1.40 billion to $1.45 billion and adjusted earnings per share of $5.00 to $5.25. This guidance did not include a material revenue contribution from products awaiting approvals during FY2026, making results primarily dependent on commercial execution for the existing portfolio.
  • Regulatory catalysts with clearly specified dates include the FDA decision on Actinium on June 29, 2026 and the PDUFA date for MK-6240 on August 13, 2026. PNT2003 also received tentative approval on March 2, 2026, while the launch timing depends on final approval and the expiration or settlement of the Hatch-Waxman stay and the related legal proceedings.
  • Buying & Selling Case

    ▲ Buying Case4 pts

    • +Lantheus has three clear commercial pillars: PYLARIFY with revenue of $240.9 million, DEFINITY with revenue of $84.6 million, and NEURACEQ with revenue of $35.4 million in Q1 FY2026. This mix combines a large established product, a stable product with market share exceeding 80%, and a neurological product that delivered quarterly growth of 14.3%.
    • +PYLARIFY TRUVU provides an opportunity to increase supply flexibility without giving up PYLARIFY's proven diagnostic characteristics, according to management. Equipping sites that produce more than 70% of doses with high-energy cyclotrons reduces the extent of modifications required to benefit from larger batches when conversion begins in Q4 FY2026.
    • +Cash generation was strong in Q1 FY2026, with operating cash flow of $125.1 million and free cash flow of $121.9 million, up $23.1 million from the comparable period. The company ended the quarter with $498.6 million in cash and cash equivalents, excluding restricted cash, in addition to an undrawn credit facility of $750 million.
    • +The advanced portfolio gives Lantheus several growth paths separate from its current products, including MK-6240, which is used in 17 pharmaceutical company-funded therapeutic programs, Lantheus 2401, which targets prostate cancer patients with negative or inconclusive PSMA imaging results, and tentatively approved PNT2003. Management is targeting an acceleration in growth beginning in FY2027 after completing the commercial and regulatory transitions planned for FY2026.

    ▼ Selling Case6 pts

    • −Revenue concentration in PYLARIFY remains high; its revenue of $240.9 million represented approximately 63.8% of total revenue in Q1 FY2026. Therefore, any decline in its net price, share, or growth in the PSMA PET market could have a disproportionate impact on Lantheus's results.
    • −The PSMA franchise faces existing competition, and management pointed to one competitor attempting to establish new product launches and another competitor losing transitional pass-through payments on October 1, 2026. PYLARIFY's net price also declined and pressured gross margin, while the company is monitoring two late-stage copper-based products and two global gallium-based products that could enter the U.S. market at later dates.
    • −Reported performance slowed in Q1 FY2026, with total revenue increasing only 1.2% year over year and PYLARIFY revenue declining 6.5% to $240.9 million, despite approximately 5.8% growth in U.S. dose volume. This divergence indicates that volume growth was insufficient to offset the effect of the prior comparison and net pricing pressure on the largest product.
    • −Management expects an adjusted gross profit margin of 65% to 66% in FY2026, below the 67.0% recorded in Q1 FY2026. Operating expenses also increased to 32.8% of revenue, deteriorating by 455 basis points year over year, due to the Evergreen and LMI operations, research investments, and preparations for the PYLARIFY TRUVU launch.
    • −The conversion from PYLARIFY to PYLARIFY TRUVU carries execution risks related to coding, coverage, and manufacturing; the company will not convert any market until the HCPCS code and transitional pass-through payments are activated and customers and insurers are ready to process claims. Each manufacturing site requires FDA approval and independent validation batches, making the pace of conversion in Q4 FY2026 dependent on multiple external parties and systems.

    Valuation

    The average analyst price target is $105.27, within a relatively wide range of $94 to $120, while the upper end of the range is above the 52-week high of $111.86 and the average remains below it. The analyst consensus is "Buy," but the breadth of the targets and the 52-week range of $49.67–$111.86 reflect varying assessments of the impact of PYLARIFY competition and margin pressures versus the opportunities from PYLARIFY TRUVU, NEURACEQ, and the regulatory portfolio; the available data do not include a valid P/E multiple that could be used as an additional valuation anchor.

    BuyAnalyst target: $105.27(+5.0%)

    Figures in the text are as of 2026-08-30; the live price is shown at the top of the page.

    FAQ

    Which products does LNTH stock rely on to generate revenue?

    LNTH relies primarily on PYLARIFY for PSMA PET imaging of prostate cancer, which generated $240.9 million in Q1 FY2026. DEFINITY, used for ultrasound imaging enhancement, generated revenue of $84.6 million with market share exceeding 80%. NEURACEQ for beta-amyloid imaging generated $35.4 million, while strategic partnerships and other activities added $16.3 million.

    How were Lantheus's results in Q2 FY2026?

    Revenue reached $388.2 million in Q2 FY2026, compared with gross profit of $241.9 million. The company reported net income of $75.0 million and earnings per share of $1.11. These results equate to a gross profit margin of approximately 62.3% and a net income margin of approximately 19.3%.

    How important is PYLARIFY TRUVU to LNTH's future?

    The FDA approved PYLARIFY TRUVU on March 6, 2026, and it offers approximately the same diagnostic characteristics and a similar safety and efficacy profile as PYLARIFY, according to management. The new formulation allows larger batches at sites equipped with high-energy cyclotrons, which produce more than 70% of PYLARIFY doses. The company is targeting a site-by-site conversion beginning in Q4 FY2026, after completing coding, coverage, and manufacturing approvals, and expects a meaningful revenue contribution in FY2027.

    Can NEURACEQ become an important growth driver for Lantheus?

    NEURACEQ generated revenue of $35.4 million in Q1 FY2026, up 14.3% compared with Q4 FY2025. The company describes it as the second most widely used and fastest-growing beta-amyloid imaging agent in the United States, without providing a numerical market share. Its manufacturing network increased to 22 sites, while Lantheus is targeting increased use within existing accounts and the addition of new accounts through its relationships with nuclear medicine departments.

    What is Lantheus's guidance for FY2026?

    On the May 7, 2026 call, management maintained its FY2026 revenue forecast of $1.40 billion to $1.45 billion. It also maintained the adjusted earnings per share range of $5.00 to $5.25, with an expected adjusted gross profit margin of 65% to 66%. This guidance does not include a material revenue contribution from products awaiting approval during FY2026, while management is targeting an acceleration in growth in FY2027.

    What are the main regulatory and leadership risks facing LNTH?

    PNT2003 received tentative approval on March 2, 2026, but its launch requires final approval and the settlement or expiration of the Hatch-Waxman stay and the related legal proceedings. The Actinium date was extended to June 29, 2026 to review manufacturing information, while MK-6240 has a PDUFA date of August 13, 2026. As of the May 7, 2026 call, Mary Heino held the positions of CEO and Executive Chair of the Board, and said the Board had narrowed its CEO search to a small number of qualified candidates, without naming a successor or specifying an appointment date.

  • −Tentative approval of PNT2003 does not mean it can be launched immediately; final approval and launch timing are tied to the expiration or settlement of the 30-month Hatch-Waxman stay and the related legal proceedings. The Actinium date was also extended by three months to June 29, 2026 to review manufacturing information, and the company did not include a material contribution from these approvals in its FY2026 revenue guidance.