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Arrowhead Pharmaceuticals announced positive Phase 3 topline results from its SHASTA-3 and SHASTA-4 studies of plozasiran, which successfully met the primary endpoint of reducing triglycerides in patients with severe hypertriglyceridemia. Following this, the CHMP issued a positive opinion recommending marketing authorization for Ubeslo and Evlarco in Europe. On July 25, NewAmsterdam Pharma and Menarini Group received this formal recommendation to advance the commercialization of these treatments.