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StocksUpdated×4•Originally published 30 April 2026•Updated 1 May 2026•

1 min read

Vanguard Expands Healthcare Footprint with 5.06% Stake in TransMedics

Key Facts

1Vanguard reported beneficial ownership of 3,533,015 shares in Protagonist Therapeutics, representing a 5.53% stake.

2The investment was disclosed as a passive stake via a Schedule 13G filing with the SEC on April 29, 2026.

Vanguard Group has further expanded its healthcare portfolio by disclosing several significant new positions in the sector. Following its 5.06% passive stake in TransMedics Group Inc (TMDX), the asset manager reported acquiring a 5.11% stake in Vericel (VCEL) and a 5.09% ownership in Travere Therapeutics (TVTX). These moves build upon Vanguard's existing presence in the biotech space, which includes previously disclosed stakes in Vaxcyte and Protagonist Therapeutics. Market participants closely monitor these filings to gauge institutional sentiment and liquidity support for medical technology and biopharmaceutical firms. Such disclosures are mandatory under SEC regulations once an institutional investor surpasses the 5% ownership threshold, signaling continued commitment to the sector's growth.

about 1 month ago

Version History

1 additional source confirmed this story

Version 4about 1 month ago

What changed: Updated the story to include Vanguard's new 5.14% stake in US Physical Therapy, expanding its healthcare portfolio following its recent investment in TransMedics.

Version 3about 1 month ago

What changed: Updated the story to include Vanguard's new disclosure of a 5.06% stake in TransMedics Group Inc.

Version 2about 1 month ago

What changed: Updated the story to include Vanguard's new disclosure of a 5.03% stake in Vaxcyte Inc, including specific voting power details.

Version 1about 1 month ago

What changed: Updated ownership percentage from 5.53% to 5.09% and added specific breakdown of voting vs. dispositive power and the filing signature date.