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Sign InBioNTech shares experienced a dramatic sell-off, falling more than 20% following a series of disappointing financial and leadership announcements. The company reported a net loss for the fourth quarter and provided full-year revenue guidance that fell short of market expectations. Adding to the downward pressure, co-founders Ugur Sahin and Ozlem Tureci announced they will step down from their roles at the end of 2026. The visionary duo, who led the development of the company's COVID-19 vaccine, revealed plans to launch a new biotechnology venture after their departure. While some analysts suggest the sharp decline could present a buying opportunity, the loss of key leadership has significantly rattled investor confidence. The market reaction underscores the critical role the founders played in BioNTech's identity and long-term valuation.